Reactome | ISG15 [cytosol]

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1169391] ISGylated PP2CB [cytosol] - Homo sapiens [Complex:R-HSA-9927392] ISGylated DDX58 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1169397] Activation of ISG15 by UBA7 E1 enzyme - Homo sapiens [Reaction:R-HSA-1169399] Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding - Homo sapiens
created	[InstanceEdit:936549] Garapati, P V, 2010-08-23
dbId	936552
displayName	ISG15 [cytosol]
endCoordinate	157
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-936552] Isg15 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-936552] Isg15 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-936552] ISG15 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-936552] ISG15 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-936552] ISG15 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-CEL-936552] ISG15 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-936552-2] ISG15 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-936552-3] ISG15 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-936552-4] ISG15 [cytosol] - Caenorhabditis elegans [DefinedSet:R-CEL-936552-5] Homologues of ISG15 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-936552] nedd8l2 [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-936552-2] ISG15 [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-936552-3] nedd8l1 [cytosol] - Dictyostelium discoideum [DefinedSet:R-DDI-936552-4] Homologues of ISG15 [cytosol] - Dictyostelium discoideum
maxDepth	1
modified	[InstanceEdit:3448660] Wu, G, 2013-05-16
name	ISG15 Interferon-induced 17 kDa protein component recommendedName: Ubiquitin cross-reactive protein UCRP_HUMAN
negativelyRegulates	[NegativeRegulation:R-HSA-1169312] Negative regulation by 'ISG15 [cytosol]'
producedByEvent	[Reaction:R-HSA-9755244] SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 - Homo sapiens [Reaction:R-HSA-9729725] SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 - Homo sapiens [BlackBoxEvent:R-HSA-1015702] Expression of IFN-induced genes - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P05161] UniProt:P05161 ISG15
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-936552
startCoordinate	2

(hasComponent)	[Complex:R-HSA-9927392] ISGylated DDX58 [cytosol] [Complex:R-HSA-1169391] ISGylated PP2CB [cytosol] [Complex:R-HSA-1169382] ISGylated E2 conjugating enzymes [cytosol] [Complex:R-HSA-1169388] ISGylated Filamin B [cytosol] [Complex:R-HSA-1169384] ISG15:NEDD4 [cytosol] [Complex:R-HSA-1678834] ISGylated 4EHP [cytosol] [Complex:R-HSA-1169387] ISGylated host proteins [cytosol] [Complex:R-HSA-1169392] ISGylated NS1 [cytosol] [Complex:R-HSA-9853032] ISG15:BECN1 [cytosol] [Complex:R-HSA-9755926] ISGylated IFIH1 [cytosol] [Complex:R-HSA-936560] ISG15:UBEIL/UbcH8:CEB1 [cytosol] [Complex:R-HSA-1169390] ISG15:UBA7 [cytosol] [Complex:R-HSA-1169385] ISG15:UBCH8 [cytosol] [Complex:R-HSA-1169389] ISGylated IRF3 [cytosol]
(regulator)	[NegativeRegulation:R-HSA-1169312] Negative regulation by 'ISG15 [cytosol]'
(input)	[Reaction:R-HSA-1169399] Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding [Reaction:R-HSA-1169397] Activation of ISG15 by UBA7 E1 enzyme
(output)	[BlackBoxEvent:R-HSA-1015702] Expression of IFN-induced genes [Reaction:R-HSA-9755244] SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1 [Reaction:R-HSA-9729725] SARS-CoV-2 nsp3 deISGylates ISGylated IRF3

ISG15 [cytosol] Show undefined attributes

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