Reactome | IRF3 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

IRF3 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9731017] IRF3:8b [cytosol] - Homo sapiens [Complex:R-HSA-9731036] IRF3:nsp3 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1834939] STING recruits TBK1 and IRF3 - Homo sapiens [Reaction:R-HSA-1834939] STING recruits TBK1 and IRF3 - Homo sapiens [Reaction:R-HSA-1606345] Recruitment of IRF3 to activated ZBP1:TBK1 - Homo sapiens [Reaction:R-HSA-1606345] Recruitment of IRF3 to activated ZBP1:TBK1 - Homo sapiens [Reaction:R-HSA-9729730] SARS-CoV-2 nsp3 cleaves IRF3 - Homo sapiens [Reaction:R-HSA-9731009] SARS-CoV-1 nsp3 binds to IRF3 - Homo sapiens [Reaction:R-HSA-9731077] SARS-CoV-1 8b binds to IRF3 - Homo sapiens [Reaction:R-HSA-1169394] ISGylation of IRF3 - Homo sapiens [Reaction:R-HSA-9709831] HSP90 binds TBK1 and IRF3 - Homo sapiens
created	[InstanceEdit:166250] de Bono, B, 2005-08-23 08:47:31
dbId	166251
displayName	IRF3 [cytosol]
endCoordinate	427
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-166251] Irf3 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-166251] Irf3 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-166251] IRF3 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-166251] IRF3 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-166251] IRF3 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-166251-2] IRF3 [cytosol] - Sus scrofa [DefinedSet:R-SSC-166251-3] Homologues of IRF3 [cytosol] - Sus scrofa [GenomeEncodedEntity:R-DRE-166251] Ghost homologue of IRF3 [cytosol] - Danio rerio [GenomeEncodedEntity:R-XTR-166251] Ghost homologue of IRF3 [cytosol] - Xenopus tropicalis [GenomeEncodedEntity:R-GGA-166251] Ghost homologue of IRF3 [cytosol] - Gallus gallus
maxDepth	1
memberOf	[DefinedSet:R-HSA-450317] IRF3,IRF7 [cytosol] - Homo sapiens [DefinedSet:R-HSA-1015695] IRF 1-9 [cytosol] - Homo sapiens
modified	[InstanceEdit:9938525] D'Eustachio, Peter, 2025-02-17
name	IRF3
producedByEvent	[Reaction:R-HSA-9729725] SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q14653] UniProt:Q14653 IRF3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-166251
startCoordinate	1
updateTrackers	[UpdateTracker:9877399] Update Tracker - [EntityWithAccessionedSequence:166251] IRF3 [cytosol] - v44:[addEndCoordinate, addStartCoordinate] [UpdateTracker:9940094] Update Tracker - [EntityWithAccessionedSequence:166251] IRF3 [cytosol] - v92:[modifyStartCoordinate] [UpdateTracker:9902242] Update Tracker - [EntityWithAccessionedSequence:166251] IRF3 [cytosol] - v77:[modifyStartCoordinate]

Referrals

(updatedInstance)	[UpdateTracker:9877399] Update Tracker - [EntityWithAccessionedSequence:166251] IRF3 [cytosol] - v44:[addEndCoordinate, addStartCoordinate] [UpdateTracker:9940094] Update Tracker - [EntityWithAccessionedSequence:166251] IRF3 [cytosol] - v92:[modifyStartCoordinate] [UpdateTracker:9902242] Update Tracker - [EntityWithAccessionedSequence:166251] IRF3 [cytosol] - v77:[modifyStartCoordinate]
(hasComponent)	[Complex:R-HSA-9731036] IRF3:nsp3 [cytosol] [Complex:R-HSA-9731017] IRF3:8b [cytosol] [Complex:R-HSA-1834956] STING:TBK1:IRF3 [cytoplasmic vesicle membrane] [Complex:R-HSA-1606328] dsDNA:ZBP1:pS-172-TBK:IRF3 [cytosol] [Complex:R-HSA-3465596] STING:p-S172,K48polyUb-TBK1:IRF3 [cytoplasmic vesicle membrane] [Complex:R-HSA-2396004] STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] [Complex:R-HSA-1169389] ISGylated IRF3 [cytosol] [Complex:R-HSA-9709836] HSP90:TBK1:IRF3 [cytosol]
(input)	[Reaction:R-HSA-9731009] SARS-CoV-1 nsp3 binds to IRF3 [Reaction:R-HSA-9731077] SARS-CoV-1 8b binds to IRF3 [Reaction:R-HSA-1834939] STING recruits TBK1 and IRF3 [Reaction:R-HSA-1606345] Recruitment of IRF3 to activated ZBP1:TBK1 [Reaction:R-HSA-1169394] ISGylation of IRF3 [Reaction:R-HSA-9729730] SARS-CoV-2 nsp3 cleaves IRF3 [Reaction:R-HSA-9709831] HSP90 binds TBK1 and IRF3
(hasMember)	[DefinedSet:R-HSA-450317] IRF3,IRF7 [cytosol] [DefinedSet:R-HSA-1015695] IRF 1-9 [cytosol]
(output)	[Reaction:R-HSA-9729725] SARS-CoV-2 nsp3 deISGylates ISGylated IRF3

Cite Us!