Reactome | Heme signaling

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Heme signaling Show undefined attributes

authored	[InstanceEdit:9707640] Stephan, Ralf, 2020-11-12
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:13231] nuclear envelope [Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9707568] Stephan, Ralf, 2020-11-19
dbId	9707616
displayName	Heme signaling
doi	10.3180/R-HSA-9707616.1
edited	[InstanceEdit:9707640] Stephan, Ralf, 2020-11-12
eventOf	[Pathway:R-HSA-2262752] Cellular responses to stress - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:9417] heme metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9707504] H2O2 oxidises ferrohemoglobin to MetHb - Homo sapiens [Reaction:R-HSA-9707516] FeHM dissociates from MetHb - Homo sapiens [Reaction:R-HSA-9707586] FeHM oxidises LDL,HDL - Homo sapiens [Reaction:R-HSA-9707594] Hemes bind LY96 - Homo sapiens [Reaction:R-HSA-9707659] Hemes:LY96 activates TLR4 - Homo sapiens [Reaction:R-HSA-9707505] Hemes bind to CLEC1B dimer - Homo sapiens [Reaction:R-HSA-917870] SLC46A1 transports hemes from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-9707683] PGRMC2 binds Hemes - Homo sapiens [BlackBoxEvent:R-HSA-9707606] PGRMC2:Hemes translocate to the nucleus - Homo sapiens [BlackBoxEvent:R-HSA-9707856] PGRMC2:Hemes dissociates - Homo sapiens [Reaction:R-HSA-9707690] BACH1 binds MAFK - Homo sapiens [BlackBoxEvent:R-HSA-9707645] HMOX1 gene produces HMOX1 dimer - Homo sapiens [Reaction:R-HSA-9707523] Hemes bind to BACH1:MAFK - Homo sapiens [Reaction:R-HSA-9708430] XPO1 (CRM1) binds to BACH1:Hemes - Homo sapiens [BlackBoxEvent:R-HSA-9708423] XPO1:BACH1:Hemes are transported out of the nucleus - Homo sapiens [Reaction:R-HSA-1368069] NR1D1 (REV-ERBA) binds heme, the BMAL1 (ARNTL) gene, and recruits corepressors - Homo sapiens [Reaction:R-HSA-5663271] NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors - Homo sapiens [Reaction:R-HSA-5663245] NR1D1 (REV-ERBA) binds heme, the NPAS2 gene, and recruits corepressors - Homo sapiens [Reaction:R-HSA-5663265] NR1D1 (REV-ERBA) binds heme, the NR1D1 gene, and recruits corepressors - Homo sapiens [Reaction:R-HSA-5663258] NR1D1 (REV-ERBA) binds heme, the PPARGC1A gene, and recruits corepressors - Homo sapiens [BlackBoxEvent:R-HSA-400342] Expression of BMAL1 (ARNTL) - Homo sapiens [BlackBoxEvent:R-HSA-1368119] Expression of CLOCK - Homo sapiens [BlackBoxEvent:R-HSA-1368065] RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 - Homo sapiens [BlackBoxEvent:R-HSA-549475] Expression of NR1D1 (REV-ERBA) - Homo sapiens [BlackBoxEvent:R-HSA-1368140] Expression of PPARGC1A (PGC-1alpha) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:9707533] Red alert: labile heme is an alarmin [LiteratureReference:9707491] TLR4 Signaling by Heme and the Role of Heme-Binding Blood Proteins [LiteratureReference:9707538] The macrophage heme-heme oxygenase-1 system and its role in inflammation [LiteratureReference:400269] Molecular components of the mammalian circadian clock
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Heme signaling
orthologousEvent	[Pathway:R-RNO-9707616] Heme signaling - Rattus norvegicus [Pathway:R-MMU-9707616] Heme signaling - Mus musculus [Pathway:R-CFA-9707616] Heme signaling - Canis familiaris [Pathway:R-BTA-9707616] Heme signaling - Bos taurus [Pathway:R-SSC-9707616] Heme signaling - Sus scrofa [Pathway:R-DRE-9707616] Heme signaling - Danio rerio [Pathway:R-XTR-9707616] Heme signaling - Xenopus tropicalis [Pathway:R-GGA-9707616] Heme signaling - Gallus gallus [Pathway:R-DME-9707616] Heme signaling - Drosophila melanogaster [Pathway:R-CEL-9707616] Heme signaling - Caenorhabditis elegans [Pathway:R-DDI-9707616] Heme signaling - Dictyostelium discoideum [Pathway:R-SPO-9707616] Heme signaling - Schizosaccharomyces pombe [Pathway:R-SCE-9707616] Heme signaling - Saccharomyces cerevisiae
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9707616
summation	[Summation:9707506] Extracellular hemoglobin, a byproduct of hemolysis, can rele...
updateTrackers	[UpdateTracker:9774976] Update Tracker - [Pathway:9707616] Heme signaling - v80:[updateContainedRLE] [UpdateTracker:9776106] Update Tracker - [Pathway:9707616] Heme signaling - v77:[updateContainedRLE] [UpdateTracker:9775747] Update Tracker - [Pathway:9707616] Heme signaling - v78:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-2262752] Cellular responses to stress
(hasEncapsulatedEvent)	[Pathway:R-HSA-189445] Metabolism of porphyrins
(updatedInstance)	[UpdateTracker:9774976] Update Tracker - [Pathway:9707616] Heme signaling - v80:[updateContainedRLE] [UpdateTracker:9776106] Update Tracker - [Pathway:9707616] Heme signaling - v77:[updateContainedRLE] [UpdateTracker:9775747] Update Tracker - [Pathway:9707616] Heme signaling - v78:[updateContainedRLE]

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