Reactome | Expression of BMAL1 (ARNTL)

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Expression of BMAL1 (ARNTL) Show undefined attributes

authored	[InstanceEdit:421369] May, B, 2009-05-17 22:04:50
category	uncertain
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:400303] May, B, 2009-03-24 02:57:07
dbId	400342
displayName	Expression of BMAL1 (ARNTL)
edited	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
eventOf	[Pathway:R-HSA-9707616] Heme signaling - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-508681] Expression of Bmal1 (Arntl) - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-5640173] ARNTL gene [nucleoplasm]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:549415] cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage [LiteratureReference:879738] Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
maxDepth	1
modified	[InstanceEdit:9938788] May, Bruce, 2025-02-19
name	Expression of BMAL1 (ARNTL) ARNTL gene produces ARNTL
output	[EntityWithAccessionedSequence:R-HSA-400353] ARNTL [cytosol]
precedingEvent	[Reaction:R-HSA-9911560] RORA,B,C, EP300, PPARGC1A, NRIP1 bind BMAL1 (ARNTL) gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-400375] Positive gene expression regulation by 'RORA:Coactivator:ARNTL gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-421342] Negative gene expression regulation by 'NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5656526] Positive gene expression regulation by 'SIRT1 [nucleoplasm]'
regulationReference	[RegulationReference:9641789] Positive gene expression regulation by 'SIRT1 [nucleoplasm]' SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging [RegulationReference:9642203] Positive gene expression regulation by 'RORA:Coactivator:ARNTL gene [nucleoplasm]' Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors [RegulationReference:9643028] Negative gene expression regulation by 'NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm]' Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422151] D'Eustachio, P, 2009-05-26 22:13:22 [InstanceEdit:879756] Albrecht, Urs, 2010-06-23 [InstanceEdit:879726] Kay, SA, 2010-06-23 [InstanceEdit:879790] Hirota, T, 2010-06-23 [InstanceEdit:879786] Delaunay, F, 2010-06-23 [InstanceEdit:9713327] Somers, Julia, 2021-01-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-400342
summation	[Summation:400357] The ARNTL (BMAL1) gene is transcribed to yield mRNA and the ... [Summation:400221] NR1D1 (REV-ERBA) binds to the same site in the promoter of t... [Summation:549489] As inferred from mouse, RORA binds RRE DNA elements and recr...
updateTrackers	[UpdateTracker:9785834] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v51:[addInput] [UpdateTracker:9775954] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v78:[addSummation] [UpdateTracker:9789094] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v38:[add_removeRegulator] [UpdateTracker:9784899] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v52:[add_removeRegulator] [UpdateTracker:9776288] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v76:[modifyText] [UpdateTracker:9776158] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v77:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785834] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v51:[addInput] [UpdateTracker:9775954] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v78:[addSummation] [UpdateTracker:9789094] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v38:[add_removeRegulator] [UpdateTracker:9784899] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v52:[add_removeRegulator] [UpdateTracker:9776288] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v76:[modifyText] [UpdateTracker:9776158] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v77:[modifyText]
(hasEvent)	[Pathway:R-HSA-9707616] Heme signaling
(inferredTo)	[BlackBoxEvent:R-MMU-508681] Expression of Bmal1 (Arntl)

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