Reactome | HMOX1 gene produces HMOX1 dimer

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HMOX1 gene produces HMOX1 dimer Show undefined attributes

authored	[InstanceEdit:9707640] Stephan, Ralf, 2020-11-12
category	uncertain
compartment	[Compartment:7660] nucleoplasm [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9707568] Stephan, Ralf, 2020-11-19
dbId	9707645
displayName	HMOX1 gene produces HMOX1 dimer
edited	[InstanceEdit:9707640] Stephan, Ralf, 2020-11-12
eventOf	[Pathway:R-HSA-9707587] Regulation of HMOX1 expression and activity - Homo sapiens [Pathway:R-HSA-9707616] Heme signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9708457] HM13 cleaves HMOX1 dimer - Homo sapiens [BlackBoxEvent:R-HSA-9708558] HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane - Homo sapiens [Reaction:R-HSA-189398] HMOX1 dimer, HMOX2 cleave heme - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6789487] HMOX1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9707697] Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells [LiteratureReference:9707521] Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HMOX1 gene produces HMOX1 dimer HMOX1 expression is repressed by BACH1:MAFK
output	[Complex:R-HSA-9706826] HMOX1 dimer [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-9707690] BACH1 binds MAFK - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:9707541] Negative gene expression regulation by 'BACH1:MAFK [nucleoplasm]' [PositiveGeneExpressionRegulation:9767064] Positive gene expression regulation by 'P-NFE2L2:MAFK [nucleoplasm]'
regulationReference	[RegulationReference:9707518] Negative gene expression regulation by 'BACH1:MAFK [nucleoplasm]' Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells [RegulationReference:9767062] Positive gene expression regulation by 'P-NFE2L2:MAFK [nucleoplasm]' Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23 [InstanceEdit:9766992] Cuadrado, Antonio, 2022-02-23
revised	[InstanceEdit:9767061] Rothfels, Karen, 2022-02-24
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9707645
summation	[Summation:9707503] Transcription regulator protein BACH1 is a critical physiolo...

Referrals

(precedingEvent)	[Reaction:R-HSA-9708457] HM13 cleaves HMOX1 dimer [BlackBoxEvent:R-HSA-9708558] HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane [Reaction:R-HSA-189398] HMOX1 dimer, HMOX2 cleave heme
(hasEvent)	[Pathway:R-HSA-9707587] Regulation of HMOX1 expression and activity [Pathway:R-HSA-9707616] Heme signaling