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Schema
>
BlackBoxEvent
>
Entries
RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2
Show undefined attributes
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authored
[InstanceEdit:1368114] May, B, 2011-06-22
category
uncertain
compartment
[Compartment:7660] nucleoplasm
[Compartment:70101] cytosol
created
[InstanceEdit:1368132] May, B, 2011-06-29
dbId
1368065
displayName
RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2
edited
[InstanceEdit:1368114] May, B, 2011-06-22
eventOf
[Pathway:R-HSA-9931509] Expression of BMAL (ARNTL), CLOCK, and NPAS2 - Homo sapiens
[Pathway:R-HSA-9707616] Heme signaling - Homo sapiens
[Pathway:R-HSA-1989781] PPARA activates gene expression - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
inferredFrom
[BlackBoxEvent:R-MMU-5663263] Expression of Npas2 - Mus musculus
input
[EntityWithAccessionedSequence:R-HSA-5640176] NPAS2 gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:1368907] Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system
[LiteratureReference:5669329] Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2 (NPAS2)
maxDepth
1
modified
[InstanceEdit:9961204] D'Eustachio, Peter, 2025-07-21
name
RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2
NPAS2 gene produces NPAS2
output
[EntityWithAccessionedSequence:R-HSA-400314] NPAS2 [cytosol]
precedingEvent
[Reaction:R-HSA-5663246] RORA and EP300 bind NPAS2 gene - Homo sapiens
[BlackBoxEvent:R-HSA-400143] Fatty acid ligands activate PPARA - Homo sapiens
regulatedBy
[NegativeGeneExpressionRegulation:R-HSA-1368161] Negative gene expression regulation by 'NR1D1:heme:Corepressors:NPAS2 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:R-HSA-1368165] Positive gene expression regulation by 'RORA:EP300:NPAS2 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:R-HSA-1989795] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]'
regulationReference
[RegulationReference:9642459] Negative gene expression regulation by 'NR1D1:heme:Corepressors:NPAS2 gene [nucleoplasm]' Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene
[RegulationReference:9642726] Positive gene expression regulation by 'RORA:EP300:NPAS2 gene [nucleoplasm]' Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene
[RegulationReference:9642870] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human
releaseDate
2011-12-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:425906] Kersten, S, 2009-06-08
[InstanceEdit:2084235] Delaunay, F, 2012-01-28
[InstanceEdit:9713327] Somers, Julia, 2021-01-23
[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14
[InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-1368065
summation
[Summation:1368066] The NPAS2 gene is transcribed to yield mRNA and the mRNA is ...
updateTrackers
[UpdateTracker:9776378] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v76:[modifyText]
[UpdateTracker:9775732] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v78:[addSummation]
[UpdateTracker:9776189] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v77:[modifyText]
[UpdateTracker:9785520] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v52:[addLiteratureReference, add_removeRegulator]
[UpdateTracker:9939733] Update Tracker - [BlackBoxEvent:1368065] RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 - v92:[addSummation, modifyText]
[UpdateTracker:9788747] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v40:[add_removeRegulator]
[UpdateTracker:9785727] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v51:[addInput]
Referrals
(updatedInstance)
[UpdateTracker:9776378] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v76:[modifyText]
[UpdateTracker:9775732] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v78:[addSummation]
[UpdateTracker:9776189] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v77:[modifyText]
[UpdateTracker:9785520] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v52:[addLiteratureReference, add_removeRegulator]
[UpdateTracker:9939733] Update Tracker - [BlackBoxEvent:1368065] RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 - v92:[addSummation, modifyText]
[UpdateTracker:9788747] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v40:[add_removeRegulator]
[UpdateTracker:9785727] Update Tracker - [BlackBoxEvent:1368065] Expression of NPAS2 - v51:[addInput]
(hasEvent)
[Pathway:R-HSA-1989781] PPARA activates gene expression
[Pathway:R-HSA-9931509] Expression of BMAL (ARNTL), CLOCK, and NPAS2
[Pathway:R-HSA-9707616] Heme signaling
(inferredTo)
[BlackBoxEvent:R-MMU-5663263] Expression of Npas2
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