Reactome | Hemes bind to BACH1:MAFK

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Hemes bind to BACH1:MAFK Show undefined attributes

authored	[InstanceEdit:9707640] Stephan, Ralf, 2020-11-12
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9707568] Stephan, Ralf, 2020-11-19
dbId	9707523
displayName	Hemes bind to BACH1:MAFK
edited	[InstanceEdit:9707640] Stephan, Ralf, 2020-11-12
eventOf	[Pathway:R-HSA-9707616] Heme signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9708430] XPO1 (CRM1) binds to BACH1:Hemes - Homo sapiens
input	[Complex:R-HSA-9707629] BACH1:MAFK [nucleoplasm] [CandidateSet:R-ALL-9707575] Hemes [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9707666] Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1 [LiteratureReference:9707681] Human heme oxygenase cDNA and induction of its mRNA by hemin [LiteratureReference:9708432] Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Hemes bind to BACH1:MAFK
orthologousEvent	[Reaction:R-DME-9707523] Hemes bind to BACH1:MAFK - Drosophila melanogaster [Reaction:R-GGA-9707523] Hemes bind to BACH1:MAFK - Gallus gallus [Reaction:R-XTR-9707523] Hemes bind to BACH1:MAFK - Xenopus tropicalis [Reaction:R-DRE-9707523] Hemes bind to BACH1:MAFK - Danio rerio [Reaction:R-SSC-9707523] Hemes bind to BACH1:MAFK - Sus scrofa [Reaction:R-BTA-9707523] Hemes bind to BACH1:MAFK - Bos taurus [Reaction:R-CFA-9707523] Hemes bind to BACH1:MAFK - Canis familiaris [Reaction:R-MMU-9707523] Hemes bind to BACH1:MAFK - Mus musculus
output	[Complex:R-HSA-9707680] BACH1:Hemes [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1008242] MAFK [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9707690] BACH1 binds MAFK - Homo sapiens [BlackBoxEvent:R-HSA-9707606] PGRMC2:Hemes translocate to the nucleus - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9713327] Somers, Julia, 2021-01-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9707523
summation	[Summation:9707520] Heme binds to four cysteine-proline motifs in the C-terminal...

Referrals

(hasEvent)	[Pathway:R-HSA-9707616] Heme signaling
(precedingEvent)	[Reaction:R-HSA-9708430] XPO1 (CRM1) binds to BACH1:Hemes