Reactome | SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2

Schema > Reaction > Entries

SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 Show undefined attributes

authored	[InstanceEdit:9705473] May, Bruce, 2020-10-18
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9705457] May, Bruce, 2020-10-24
dbId	9705467
displayName	SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
edited	[InstanceEdit:9705473] May, Bruce, 2020-10-18
eventOf	[Pathway:R-HSA-9705462] Inactivation of CSF3 (G-CSF) signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9705726] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed - Homo sapiens
inferredFrom	[Reaction:R-MMU-9705471] Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 - Mus musculus
input	[Complex:R-HSA-9676067] CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [plasma membrane] 2 × [DefinedSet:R-HSA-877267] SOCS-1 and SOCS-3 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9705427] Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction [LiteratureReference:9708245] Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
output	[Complex:R-HSA-9705439] SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9705466] p-Y-STAT1,3,5 dimer enhances expression of SOCS1 - Homo sapiens [BlackBoxEvent:R-HSA-9705458] p-Y-STAT1,3,5 dimer enhances expression of SOCS3 - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9705467
summation	[Summation:9705477] SOCS3 (Hortner et al. 2002) or SOCS1 binds phosphotyrosine-7...

Referrals

(hasEvent)	[Pathway:R-HSA-9705462] Inactivation of CSF3 (G-CSF) signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-9705726] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
(inferredTo)	[Reaction:R-MMU-9705471] Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2

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