Reactome | SOCS-1 and SOCS-3 [cytosol]

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SOCS-1 and SOCS-3 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9705731] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] - Homo sapiens [Complex:R-HSA-9705731] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] - Homo sapiens [Complex:R-HSA-976147] RBX1-CUL5-EloB/C-SOCS [cytosol] - Homo sapiens [Complex:R-HSA-912684] p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-912680] Inhibition of JAK kinase activity by SOCS1/3 - Homo sapiens [Reaction:R-HSA-9705467] SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 - Homo sapiens [Reaction:R-HSA-9705467] SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 - Homo sapiens [Reaction:R-HSA-877269] SOCS-1 and SOCS-3 binds to p-JAK2 - Homo sapiens
created	[InstanceEdit:877268] Garapati, P V, 2010-06-11
dbId	877267
displayName	SOCS-1 and SOCS-3 [cytosol]
hasMember	[EntityWithAccessionedSequence:R-HSA-204910] SOCS1 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-873794] SOCS3 [cytosol] - Homo sapiens
inDisease	false
inferredTo	[DefinedSet:R-MMU-877267] SOCS-1 and SOCS-3 [cytosol] - Mus musculus [DefinedSet:R-RNO-877267] SOCS-1 and SOCS-3 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-873794] SOCS3 [cytosol] - Canis familiaris [DefinedSet:R-BTA-877267] SOCS-1 and SOCS-3 [cytosol] - Bos taurus [DefinedSet:R-SSC-877267] SOCS-1 and SOCS-3 [cytosol] - Sus scrofa [DefinedSet:R-DRE-877267] SOCS-1 and SOCS-3 [cytosol] - Danio rerio [DefinedSet:R-XTR-877267] SOCS-1 and SOCS-3 [cytosol] - Xenopus tropicalis [DefinedSet:R-GGA-877267] SOCS-1 and SOCS-3 [cytosol] - Gallus gallus [GenomeEncodedEntity:R-DME-877267] Ghost homologue of SOCS-1 and SOCS-3 [cytosol] - Drosophila melanogaster [GenomeEncodedEntity:R-CEL-877267] Ghost homologue of SOCS-1 and SOCS-3 [cytosol] - Caenorhabditis elegans
maxDepth	2
modified	[InstanceEdit:877278] Garapati, P V, 2010-06-11
name	SOCS-1 and SOCS-3
producedByEvent	[BlackBoxEvent:R-HSA-9705738] SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 - Homo sapiens [BlackBoxEvent:R-HSA-9705738] SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-877267

Referrals

(output)	[BlackBoxEvent:R-HSA-9705738] SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
(input)	[Reaction:R-HSA-9705467] SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [Reaction:R-HSA-912680] Inhibition of JAK kinase activity by SOCS1/3 [Reaction:R-HSA-877269] SOCS-1 and SOCS-3 binds to p-JAK2
(hasComponent)	[Complex:R-HSA-9705731] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] [Complex:R-HSA-9705439] SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] [Complex:R-HSA-912684] p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] [Complex:R-HSA-976147] RBX1-CUL5-EloB/C-SOCS [cytosol] [Complex:R-HSA-873821] IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane]
(activeUnit)	[NegativeRegulation:9707970] Negative regulation by 'SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane]' [NegativeRegulation:R-HSA-912708] Negative regulation by 'p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane]' [NegativeRegulation:R-HSA-877306] Negative regulation by 'IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane]'

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