Reactome | Inactivation of CSF3 (G-CSF) signaling

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Inactivation of CSF3 (G-CSF) signaling Show undefined attributes

authored	[InstanceEdit:9705473] May, Bruce, 2020-10-18
created	[InstanceEdit:9705457] May, Bruce, 2020-10-24
crossReference	[DatabaseIdentifier:12819653] BioModels Database:BIOMD0000001077 [DatabaseIdentifier:12819655] BioModels Database:BIOMD0000000314 [DatabaseIdentifier:12819447] BioModels Database:BIOMD0000000504 [DatabaseIdentifier:12819657] BioModels Database:BIOMD0000000313 [DatabaseIdentifier:12819649] BioModels Database:BIOMD0000000968 [DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	9705462
displayName	Inactivation of CSF3 (G-CSF) signaling
edited	[InstanceEdit:9705473] May, Bruce, 2020-10-18
eventOf	[Pathway:R-HSA-9674555] Signaling by CSF3 (G-CSF) - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9705461] p-Y-STAT1,3,5 dimer binds SOCS1 gene - Homo sapiens [Reaction:R-HSA-9705465] p-Y-STAT1,3,5 dimer binds SOCS3 gene - Homo sapiens [BlackBoxEvent:R-HSA-9705466] p-Y-STAT1,3,5 dimer enhances expression of SOCS1 - Homo sapiens [BlackBoxEvent:R-HSA-9705458] p-Y-STAT1,3,5 dimer enhances expression of SOCS3 - Homo sapiens [Reaction:R-HSA-9705467] SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 - Homo sapiens [BlackBoxEvent:R-HSA-9705726] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed - Homo sapiens [Reaction:R-HSA-9705729] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 - Homo sapiens [BlackBoxEvent:R-HSA-9705738] SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 - Homo sapiens [BlackBoxEvent:R-HSA-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9708237] Scratching the surface: signaling and routing dynamics of the CSF3 receptor [LiteratureReference:9708243] G-CSF and its receptor in myeloid malignancy [LiteratureReference:9705427] Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction [LiteratureReference:9708245] Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling [LiteratureReference:9707882] Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kinetics [LiteratureReference:9707879] Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia [LiteratureReference:9707892] Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor [LiteratureReference:9707890] Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Inactivation of CSF3 (G-CSF) signaling
orthologousEvent	[Pathway:R-GGA-9705462] Inactivation of CSF3 (G-CSF) signaling - Gallus gallus [Pathway:R-XTR-9705462] Inactivation of CSF3 (G-CSF) signaling - Xenopus tropicalis [Pathway:R-DRE-9705462] Inactivation of CSF3 (G-CSF) signaling - Danio rerio [Pathway:R-SSC-9705462] Inactivation of CSF3 (G-CSF) signaling - Sus scrofa [Pathway:R-BTA-9705462] Inactivation of CSF3 (G-CSF) signaling - Bos taurus [Pathway:R-CFA-9705462] Inactivation of CSF3 (G-CSF) signaling - Canis familiaris [Pathway:R-RNO-9705462] Inactivation of CSF3 (G-CSF) signaling - Rattus norvegicus [Pathway:R-MMU-9705462] Inactivation of CSF3 (G-CSF) signaling - Mus musculus
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9705462
summation	[Summation:9708241] Signaling by CSF3 causes its own inactivation, thereby preve...

Referrals

(hasEvent)

[Pathway:R-HSA-9674555] Signaling by CSF3 (G-CSF)

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