Reactome | p-Y-STAT1,3,5 dimer enhances expression of SOCS1

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:9705473] May, Bruce, 2020-10-18
category	uncertain
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9705457] May, Bruce, 2020-10-24
dbId	9705466
displayName	p-Y-STAT1,3,5 dimer enhances expression of SOCS1
edited	[InstanceEdit:9705473] May, Bruce, 2020-10-18
eventOf	[Pathway:R-HSA-9705462] Inactivation of CSF3 (G-CSF) signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9705467] SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9705455] p-Y-Stat1,3,5 dimer enhances expression of Socs1 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-6786291] SOCS1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-Y-STAT1,3,5 dimer enhances expression of SOCS1
output	[EntityWithAccessionedSequence:R-HSA-204910] SOCS1 [cytosol]
precedingEvent	[Reaction:R-HSA-9705461] p-Y-STAT1,3,5 dimer binds SOCS1 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9705474] Positive gene expression regulation by 'p-Y-STAT1,3,5 dimer:SOCS1 gene [nucleoplasm]'
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9705466
summation	[Summation:9708231] The SOCS1 gene is transcribed to yield mRNA and the mRNA is ...

(hasEvent)	[Pathway:R-HSA-9705462] Inactivation of CSF3 (G-CSF) signaling
(precedingEvent)	[Reaction:R-HSA-9705467] SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
(inferredTo)	[BlackBoxEvent:R-MMU-9705455] p-Y-Stat1,3,5 dimer enhances expression of Socs1

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