SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2

Stable Identifier
R-HSA-9705467
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2
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SOCS3 (Hortner et al. 2002) or SOCS1 binds phosphotyrosine-729 (phosphotyrosine-727 of isoform 1) of CSF3R. SOCS3 also interacts with phosphotyrosine-1007 of JAK2 (Sasaki et al. 1999). SOCS1 and especially SOCS3 inhibit the phosphorylation activity of JAK2 (van de Geijn et al. 2004).

Literature References
PubMed ID Title Journal Year
12133942 Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction

Johnston, JA, Nielsch, U, Haan, S, Hörtner, M, Mayr, LM, Heinrich, PC

J Immunol 2002
15107455 Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling

Gits, J, van de Geijn, GJ, Touw, IP

J Leukoc Biol 2004
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Inferred From
Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 (Mus musculus)
Authored
May, B  (2020-10-18)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-10-24)
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