SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2

Stable Identifier
R-HSA-9705467
Type
Reaction [binding]
Species
Homo sapiens
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SOCS3 (Hortner et al. 2002) or SOCS1 binds phosphotyrosine-729 (phosphotyrosine-727 of isoform 1) of CSF3R. SOCS3 also interacts with phosphotyrosine-1007 of JAK2 (Sasaki et al. 1999). SOCS1 and especially SOCS3 inhibit the phosphorylation activity of JAK2 (van de Geijn et al. 2004).

Literature References
PubMed ID Title Journal Year
15107455 Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling

van de Geijn, GJ, Gits, J, Touw, IP

J Leukoc Biol 2004
12133942 Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction

Hörtner, M, Nielsch, U, Mayr, LM, Johnston, JA, Heinrich, PC, Haan, S

J Immunol 2002
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