Reactome | SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed

Schema > BlackBoxEvent > Entries

SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed Show undefined attributes

authored	[InstanceEdit:9705725] May, Bruce, 2020-10-24
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:24337] endocytic vesicle membrane
created	[InstanceEdit:9705735] May, Bruce, 2020-10-30
dbId	9705726
displayName	SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
edited	[InstanceEdit:9705725] May, Bruce, 2020-10-24
eventOf	[Pathway:R-HSA-9705462] Inactivation of CSF3 (G-CSF) signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9705729] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9707979] Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed - Mus musculus
input	[Complex:R-HSA-9705439] SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9707882] Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kinetics [LiteratureReference:9707879] Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia [LiteratureReference:9707892] Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed
output	[Complex:R-HSA-9705731] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane]
precedingEvent	[Reaction:R-HSA-9705467] SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9705726
summation	[Summation:9707976] After binding CSF3 (G-CSF), the CSF3 receptor CSF3R is inter...

Referrals

(hasEvent)	[Pathway:R-HSA-9705462] Inactivation of CSF3 (G-CSF) signaling
(precedingEvent)	[Reaction:R-HSA-9705729] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7
(inferredTo)	[BlackBoxEvent:R-MMU-9707979] Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed

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