Reactome | CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane

Schema > BlackBoxEvent > Entries

CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane Show undefined attributes

authored	[InstanceEdit:9707978] May, Bruce, 2020-11-09
category	omitted
compartment	[Compartment:24337] endocytic vesicle membrane [Compartment:17938] lysosomal membrane
created	[InstanceEdit:9707968] May, Bruce, 2020-11-21
dbId	9707977
displayName	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
edited	[InstanceEdit:9707978] May, Bruce, 2020-11-09
eventOf	[Pathway:R-HSA-9705462] Inactivation of CSF3 (G-CSF) signaling - Homo sapiens
input	[Complex:R-HSA-9707902] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9707890] Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor [LiteratureReference:9707892] Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor [LiteratureReference:9707882] Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kinetics
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane
orthologousEvent	[BlackBoxEvent:R-GGA-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Gallus gallus [BlackBoxEvent:R-XTR-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Xenopus tropicalis [BlackBoxEvent:R-DRE-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Danio rerio [BlackBoxEvent:R-SSC-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Sus scrofa [BlackBoxEvent:R-BTA-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Bos taurus [BlackBoxEvent:R-CFA-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Canis familiaris [BlackBoxEvent:R-RNO-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Rattus norvegicus [BlackBoxEvent:R-MMU-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Mus musculus
output	[Complex:R-HSA-9707927] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9705738] SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9707977
summation	[Summation:9707975] Polyubiquitinated CSF3R, believed to be in a complex with wi...

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(hasEvent)

[Pathway:R-HSA-9705462] Inactivation of CSF3 (G-CSF) signaling

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