Reactome | Inactivation of CSF3 (G-CSF) signaling

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Inactivation of CSF3 (G-CSF) signaling Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225353
displayName	Inactivation of CSF3 (G-CSF) signaling
eventOf	[Pathway:R-RNO-9674555] Signaling by CSF3 (G-CSF) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-RNO-9705738] SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 - Rattus norvegicus [BlackBoxEvent:R-RNO-9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9705462] Inactivation of CSF3 (G-CSF) signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Inactivation of CSF3 (G-CSF) signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9705462
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9674555] Signaling by CSF3 (G-CSF)
(inferredTo)	[Pathway:R-HSA-9705462] Inactivation of CSF3 (G-CSF) signaling

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