Reactome | quizartinib-sensitive FLT3 mutants [plasma membrane]

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quizartinib-sensitive FLT3 mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9699531
disease	[Disease:1500689] cancer
displayName	quizartinib-sensitive FLT3 mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9699437] FLT3 Y597_E598insDEDFYVDFREY [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699445] FLT3 V592_E598dup [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699438] FLT3 L601_L610dup [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682321] FLT3 D835N [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682304] FLT3 D835H [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9699426] FLT3 F621L [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9691903] FLT3 Y591_V592insVDFREYEYDH [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682301] FLT3 D835G [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9699282] FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27^Kip1 in acute myeloid leukemia [LiteratureReference:9699248] Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants [LiteratureReference:9699345] Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors [LiteratureReference:9699359] Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns [LiteratureReference:9702954] FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors
maxDepth	2
memberOf	[DefinedSet:R-HSA-9702524] type II TKI sensitive FLT3 mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9703028] Rothfels, Karen, 2020-10-03
name	quizartinib-sensitive FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9699531

Referrals

(hasMember)

[DefinedSet:R-HSA-9702524] type II TKI sensitive FLT3 mutants [plasma membrane]

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