Reactome | FLT3 Y591_V592insVDFREYEYDH [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9691983] FLT3 Y591_V592insVDFREYEYDH dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9691897] Rothfels, Karen, 2020-06-19
dbId	9691903
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 Y591_V592insVDFREYEYDH [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentReplacedModification:9691892] Replacement of residues 591 to 592 by YVDFREYEYDHV
inDisease	true
literatureReference	[LiteratureReference:9691830] SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase
memberOf	[DefinedSet:R-HSA-9703020] ponatinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699531] quizartinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens
name	FLT3 Y591_V592insVDFREYEYDH STK-1 MV4;11
referenceEntity	[ReferenceGeneProduct:54914] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9691903
startCoordinate	27

(hasMember)	[DefinedSet:R-HSA-9699531] quizartinib-sensitive FLT3 mutants [plasma membrane] [DefinedSet:R-HSA-9703020] ponatinib-sensitive FLT3 mutants [plasma membrane] [DefinedSet:R-HSA-9699532] sunitinib-sensitive FLT3 mutants [plasma membrane] [CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9691983] FLT3 Y591_V592insVDFREYEYDH dimer [plasma membrane]

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