Reactome | FLT3 F621L [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9699494] FLT3 F621L dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699494] FLT3 F621L dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9699450] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874
dbId	9699426
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 F621L [plasma membrane]
endCoordinate	993
hasModifiedResidue	[ReplacedResidue:9699424] L-phenylalanine 621 replaced with L-leucine
inDisease	true
literatureReference	[LiteratureReference:9699345] Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors
maxDepth	1
memberOf	[DefinedSet:R-HSA-9699522] sorafenib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-9699531] quizartinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens
name	FLT3 F621L
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699426
startCoordinate	27

(hasMember)	[DefinedSet:R-HSA-9699531] quizartinib-sensitive FLT3 mutants [plasma membrane] [DefinedSet:R-HSA-9699522] sorafenib-sensitive FLT3 mutants [plasma membrane]
(hasComponent)	[Complex:R-HSA-9699494] FLT3 F621L dimer [plasma membrane]

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