Reactome | FLT3 Y597_E598insDEDFYVDFREY [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

FLT3 Y597_E598insDEDFYVDFREY [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9699485] FLT3 E598_Y599insFYVDFREY dimer [plasma membrane] - Homo sapiens [Complex:R-HSA-9699485] FLT3 E598_Y599insFYVDFREY dimer [plasma membrane] - Homo sapiens
created	[InstanceEdit:9699450] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020776] Mondo:0018874
dbId	9699437
disease	[Disease:1500689] cancer [Disease:9630839] acute myeloid leukemia
displayName	FLT3 Y597_E598insDEDFYVDFREY [plasma membrane]
endCoordinate	993
hasModifiedResidue	[FragmentReplacedModification:9699419] Replacement of residues 597 to 598 by YDEDFYVDFREYE
inDisease	true
literatureReference	[LiteratureReference:9699298] FLT3 receptors with internal tandem duplications promote cell viability and proliferation by signaling through Foxo proteins
maxDepth	1
memberOf	[DefinedSet:R-HSA-9699531] quizartinib-sensitive FLT3 mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9832456] Orlic-Milacic, Marija, 2023-04-01
name	FLT3 Y597_E598insDEDFYVDFREY ITD4
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-9699437
startCoordinate	27
updateTrackers	[UpdateTracker:9905664] Update Tracker - [EntityWithAccessionedSequence:9699437] FLT3 Y597_E598insDEDFYVDFREY [plasma membrane] - v85:[modifyName, removeHasModifiedResidue]

Referrals

(updatedInstance)	[UpdateTracker:9905664] Update Tracker - [EntityWithAccessionedSequence:9699437] FLT3 Y597_E598insDEDFYVDFREY [plasma membrane] - v85:[modifyName, removeHasModifiedResidue]
(hasMember)	[DefinedSet:R-HSA-9699531] quizartinib-sensitive FLT3 mutants [plasma membrane] [CandidateSet:R-HSA-9691152] juxtamembrane domain mutants of FLT3 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9699485] FLT3 E598_Y599insFYVDFREY dimer [plasma membrane]

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