Reactome | RB1 recruits APC/C:Cdh1 complex to SKP2

Schema > Reaction > Entries

RB1 recruits APC/C:Cdh1 complex to SKP2 Show undefined attributes

authored	[InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9686975] Orlic-Milacic, Marija, 2020-05-05
dbId	9686980
diseaseReaction	[FailedReaction:R-HSA-9687377] Defective RB1 does not form a complex with SKP2 and FZR1 - Homo sapiens
displayName	RB1 recruits APC/C:Cdh1 complex to SKP2
edited	[InstanceEdit:9689364] Orlic-Milacic, Marija, 2020-05-18
eventOf	[Pathway:R-HSA-174178] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 - Homo sapiens
followingEvent	[Reaction:R-HSA-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Homo sapiens
input	[Complex:R-HSA-174250] Cdh1:phospho-APC/C complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-68642] RB1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-975554] SKP2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9686974] An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant [LiteratureReference:9686977] Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	RB1 recruits APC/C:Cdh1 complex to SKP2
negativePrecedingEvent	[NegativePrecedingEvent:9764120] Futile Cycle: APC/C:Cdh1-mediated degradation of Skp2
orthologousEvent	[Reaction:R-DME-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Drosophila melanogaster [Reaction:R-GGA-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Gallus gallus [Reaction:R-SSC-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Sus scrofa [Reaction:R-BTA-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Bos taurus [Reaction:R-RNO-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Rattus norvegicus [Reaction:R-MMU-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Mus musculus
output	[Complex:R-HSA-9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9659820] RB1 translocates to the nucleus - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9686980
summation	[Summation:9686970] The pocket domain of the RB1 tumor suppressor protein binds ...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9687377] Defective RB1 does not form a complex with SKP2 and FZR1
(hasEvent)	[Pathway:R-HSA-174178] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
(precedingEvent)	[Reaction:R-HSA-9686969] APC/C:Cdh1 polyubiquitinates SKP2