Reactome | Defective RB1 does not form a complex with SKP2 and FZR1

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Defective RB1 does not form a complex with SKP2 and FZR1 Show undefined attributes

authored	[InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9687378] Orlic-Milacic, Marija, 2020-05-07
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9687377
disease	[Disease:1500689] cancer
displayName	Defective RB1 does not form a complex with SKP2 and FZR1
edited	[InstanceEdit:9689368] Orlic-Milacic, Marija, 2020-05-18
entityFunctionalStatus	[EntityFunctionalStatus:9687399] loss_of_function of RB1 T738_R775del [nucleoplasm]
eventOf	[Pathway:R-HSA-9687136] Aberrant regulation of mitotic exit in cancer due to RB1 defects - Homo sapiens
input	[Complex:R-HSA-174250] Cdh1:phospho-APC/C complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9661042] RB1 T738_R775del [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-975554] SKP2 [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9686977] Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit [LiteratureReference:9686974] An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective RB1 does not form a complex with SKP2 and FZR1
normalReaction	[Reaction:R-HSA-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9687377
summation	[Summation:9687395] A tripartite complex formed between RB1, SKP2 and FZR1 (Cdh1...

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(hasEvent)

[Pathway:R-HSA-9687136] Aberrant regulation of mitotic exit in cancer due to RB1 defects

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