Reactome | Cdh1:phospho-APC/C complex [nucleoplasm]

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Cdh1:phospho-APC/C complex [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm] - Homo sapiens [Complex:R-HSA-3788733] EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] - Homo sapiens [Complex:R-HSA-3788739] Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] - Homo sapiens
consumedByEvent	[FailedReaction:R-HSA-9687377] Defective RB1 does not form a complex with SKP2 and FZR1 - Homo sapiens [Reaction:R-HSA-3788725] Cdh1:APC/C complex binds EHMT1:EHMT2 - Homo sapiens [Reaction:R-HSA-3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 - Homo sapiens [Reaction:R-HSA-188371] Association of Cyclin A:Cdk2 with Cdh1 - Homo sapiens [Reaction:R-HSA-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Homo sapiens
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
dbId	174250
displayName	Cdh1:phospho-APC/C complex [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-174099] FZR1 [nucleoplasm] [Complex:R-HSA-174109] phosphorylated anaphase promoting complex (APC/C) [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Mus musculus [Complex:R-RNO-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Canis familiaris [Complex:R-BTA-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Bos taurus [Complex:R-SSC-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Sus scrofa [Complex:R-DRE-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Danio rerio [Complex:R-XTR-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Gallus gallus [Complex:R-DME-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Drosophila melanogaster [Complex:R-DDI-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Dictyostelium discoideum [Complex:R-SPO-174250] Cdh1:phospho-APC/C complex [nucleoplasm] - Schizosaccharomyces pombe
maxDepth	3
modified	[InstanceEdit:177819] Matthews, L, 2006-04-09 22:47:24
name	Cdh1:phospho-APC/C complex
positivelyRegulates	[PositiveRegulation:R-HSA-3790134] Positive regulation by 'Cdh1:phospho-APC/C complex [nucleoplasm]' [PositiveRegulation:R-HSA-3790136] Positive regulation by 'Cdh1:phospho-APC/C complex [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-HSA-188191] APC/C:Cdh1-mediated degradation of Skp2 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-174250
updateTrackers	[UpdateTracker:9893318] Update Tracker - [Complex:174250] Cdh1:phospho-APC/C complex [nucleoplasm] - v55:[updateContainedComponent] [UpdateTracker:9901218] Update Tracker - [Complex:174250] Cdh1:phospho-APC/C complex [nucleoplasm] - v73:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9893318] Update Tracker - [Complex:174250] Cdh1:phospho-APC/C complex [nucleoplasm] - v55:[updateContainedComponent] [UpdateTracker:9901218] Update Tracker - [Complex:174250] Cdh1:phospho-APC/C complex [nucleoplasm] - v73:[updateContainedComponent]
(input)	[FailedReaction:R-HSA-9687377] Defective RB1 does not form a complex with SKP2 and FZR1 [Reaction:R-HSA-3788725] Cdh1:APC/C complex binds EHMT1:EHMT2 [Reaction:R-HSA-3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 [Reaction:R-HSA-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 [Reaction:R-HSA-188371] Association of Cyclin A:Cdk2 with Cdh1
(regulator)	[PositiveRegulation:R-HSA-3790134] Positive regulation by 'Cdh1:phospho-APC/C complex [nucleoplasm]' [PositiveRegulation:R-HSA-3790136] Positive regulation by 'Cdh1:phospho-APC/C complex [nucleoplasm]'
(hasComponent)	[Complex:R-HSA-3788739] Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] [Complex:R-HSA-3788733] EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] [Complex:R-HSA-9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm] [Complex:R-HSA-188192] PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm] [Complex:R-HSA-188374] Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm]
(output)	[BlackBoxEvent:R-HSA-188191] APC/C:Cdh1-mediated degradation of Skp2

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