Reactome | APC/C:Cdh1 polyubiquitinates SKP2

Schema > Reaction > Entries

APC/C:Cdh1 polyubiquitinates SKP2 Show undefined attributes

authored	[InstanceEdit:9687445] Orlic-Milacic, Marija, 2020-05-07
catalystActivity	[CatalystActivity:9687072] ubiquitin protein ligase activity of RB1:SKP2:APC/C:Cdh1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9686975] Orlic-Milacic, Marija, 2020-05-05
dbId	9686969
displayName	APC/C:Cdh1 polyubiquitinates SKP2
edited	[InstanceEdit:9689364] Orlic-Milacic, Marija, 2020-05-18
eventOf	[Pathway:R-HSA-174178] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-188191] APC/C:Cdh1-mediated degradation of Skp2 - Homo sapiens
input	[Complex:R-HSA-9686978] RB1:SKP2:APC/C:Cdh1 [nucleoplasm] 3 × [DefinedSet:R-HSA-68524] Ub [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9686977] Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	APC/C:Cdh1 polyubiquitinates SKP2
negativePrecedingEvent	[NegativePrecedingEvent:9764079] Futile Cycle: APC/C:Cdh1-mediated degradation of Skp2 [NegativePrecedingEvent:9764078] Futile Cycle: Degradation of multiubiquitinated Cdh1
orthologousEvent	[Reaction:R-DDI-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Dictyostelium discoideum [Reaction:R-DME-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Drosophila melanogaster [Reaction:R-GGA-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Gallus gallus [Reaction:R-XTR-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Xenopus tropicalis [Reaction:R-DRE-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Danio rerio [Reaction:R-SSC-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Sus scrofa [Reaction:R-BTA-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Bos taurus [Reaction:R-CFA-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Canis familiaris [Reaction:R-RNO-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Rattus norvegicus [Reaction:R-MMU-9686969] APC/C:Cdh1 polyubiquitinates SKP2 - Mus musculus
output	[Complex:R-HSA-188192] PolyUb-SKP2:RB1:phospho-APC/C:Cdh1 complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9686980] RB1 recruits APC/C:Cdh1 complex to SKP2 - Homo sapiens
releaseDate	2020-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9689366] Dick, Frederick Andrew, 2020-05-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9686969
summation	[Summation:9687088] RB1-dependent polyubiquitination of SKP2 by the APC/C:Cdh1 c...

Referrals

(hasEvent)	[Pathway:R-HSA-174178] APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
(precedingEvent)	[BlackBoxEvent:R-HSA-188191] APC/C:Cdh1-mediated degradation of Skp2