Reactome | pexidartinib-resistant FLT3 mutants [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9702607] pexidartinib-resistant FLT3 mutants don't bind pexidartinib - Homo sapiens
created	[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9699534
disease	[Disease:1500689] cancer
displayName	pexidartinib-resistant FLT3 mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9682313] FLT3 D835F [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682304] FLT3 D835H [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682321] FLT3 D835N [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682323] FLT3 D835V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682353] FLT3 D835Y [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9699279] FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors [LiteratureReference:9703039] Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397
maxDepth	2
modified	[InstanceEdit:9703078] Rothfels, Karen, 2020-10-05
name	pexidartinib-resistant FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9699534

(input)	[FailedReaction:R-HSA-9702607] pexidartinib-resistant FLT3 mutants don't bind pexidartinib
(diseaseEntity)	[EntityFunctionalStatus:9702608] loss_of_function of pexidartinib-resistant FLT3 mutants [plasma membrane]