Reactome | ponatinib-resistant FLT3 mutants [plasma membrane]

Schema > DefinedSet > Entries

ponatinib-resistant FLT3 mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
consumedByEvent	[FailedReaction:R-HSA-9702613] ponatinib-resistant FLT3 mutants don't bind ponatinib - Homo sapiens
created	[InstanceEdit:9699524] Rothfels, Karen, 2020-09-14
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	9699527
disease	[Disease:1500689] cancer
displayName	ponatinib-resistant FLT3 mutants [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-9682290] FLT3 D835A [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682313] FLT3 D835F [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682304] FLT3 D835H [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682323] FLT3 D835V [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9682353] FLT3 D835Y [plasma membrane] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:9695648] Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD [LiteratureReference:9699279] FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors [LiteratureReference:9699393] Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia [LiteratureReference:9702954] FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors
maxDepth	2
modified	[InstanceEdit:9703028] Rothfels, Karen, 2020-10-03
name	ponatinib-resistant FLT3 mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-9699527

Referrals

(input)	[FailedReaction:R-HSA-9702613] ponatinib-resistant FLT3 mutants don't bind ponatinib
(diseaseEntity)	[EntityFunctionalStatus:9702611] loss_of_function of ponatinib-resistant FLT3 mutants [plasma membrane]

© 2026 Reactome

Cite Us!