Reactome | ERBB2 ECD mutants bind TKIs

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ERBB2 ECD mutants bind TKIs Show undefined attributes

authored	[InstanceEdit:9665414] Orlic-Milacic, Marija, 2019-10-30
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9665414] Orlic-Milacic, Marija, 2019-10-30
dbId	9665412
disease	[Disease:1500689] cancer
displayName	ERBB2 ECD mutants bind TKIs
edited	[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019-11-01
entityFunctionalStatus	[EntityFunctionalStatus:9665378] gain_of_function of ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
eventOf	[Pathway:R-HSA-9665348] Signaling by ERBB2 ECD mutants - Homo sapiens
input	[DefinedSet:R-HSA-1237431] afatinib, neratinib, lapatinib [cytosol] [Complex:R-HSA-9665377] ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer [LiteratureReference:9665365] Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ERBB2 ECD mutants bind TKIs
normalReaction	[Reaction:R-HSA-9652264] ERBB2 binds TKIs
output	[Complex:R-HSA-9665467] ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9666036] Bose, Ron, 2019-10-25 [InstanceEdit:9666034] Krishna, Anagha, 2019-10-25 [InstanceEdit:9666741] Kancha, Rama Krishna, 2019-11-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9665412
summation	[Summation:9665477] Comapred with the wild type ERBB2, ERBB2 G309E, ERBB2 S310F ...

Referrals

(hasEvent)

[Pathway:R-HSA-9665348] Signaling by ERBB2 ECD mutants