Reactome | Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2

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Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2 Show undefined attributes

author	[Person:1169426] Greulich, H [Person:9652912] Kaplan, B [Person:6789441] Mertins, P [Person:9665368] Chen, TH [Person:9665369] Tanaka, KE [Person:5362601] Yun, CH [Person:3214853] Zhang, X [Person:8853022] Lee, SH [Person:1982011] Cho, J [Person:8850981] Ambrogio, L [Person:9665373] Liao, R [Person:9665372] Imielinski, M [Person:9665364] Banerji, S [Person:9665371] Berger, AH [Person:3656319] Lawrence, MS [Person:6802137] Zhang, J [Person:9665366] Pho, NH [Person:9665363] Walker, SR [Person:1614729] Winckler, W [Person:2008151] Getz, G [Person:9665370] Frank, D [Person:2011584] Hahn, WC [Person:2408401] Eck, MJ [Person:9665374] Mani, DR [Person:5432417] Jaffe, JD [Person:200243] Carr, SA [Person:1182963] Wong, KK [Person:1169419] Meyerson, M
created	[InstanceEdit:9665367] Orlic-Milacic, Marija, 2019-10-30
dbId	9665365
displayName	Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
journal	Proc. Natl. Acad. Sci. U.S.A.
pages	14476-81
pubMedIdentifier	22908275
schemaClass	LiteratureReference
title	Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
url	http://www.ncbi.nlm.nih.gov/pubmed/22908275
volume	109
year	2012

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[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer
[Pathway:R-HSA-9665348] Signaling by ERBB2 ECD mutants
[EntityWithAccessionedSequence:R-HSA-9665385] p-6Y-ERBB2 S310Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665379] p-6Y-ERBB2 S310F [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665382] p-6Y-ERBB2 G309E [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665344] ERBB2 S310Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665350] ERBB2 S310F [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665342] ERBB2 G309E [plasma membrane]
[Reaction:R-HSA-9665388] ERBB2 ECD mutants heterodimerize with EGFR
[Reaction:R-HSA-9665389] Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate
[Reaction:R-HSA-9665417] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1
[Reaction:R-HSA-9665415] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
[Reaction:R-HSA-9665407] PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3
[Reaction:R-HSA-9665416] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1
[Reaction:R-HSA-9665406] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1
[Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab
[Reaction:R-HSA-9665413] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1
[Reaction:R-HSA-9665404] RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1
[Reaction:R-HSA-9665410] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1
[Reaction:R-HSA-9665411] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1
[Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR
[Reaction:R-HSA-9665408] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
[Reaction:R-HSA-9665412] ERBB2 ECD mutants bind TKIs

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