Reactome | ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9665468] ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] - Homo sapiens [Complex:R-HSA-9665467] ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9665412] ERBB2 ECD mutants bind TKIs - Homo sapiens [Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab - Homo sapiens [Reaction:R-HSA-9665388] ERBB2 ECD mutants heterodimerize with EGFR - Homo sapiens
created	[InstanceEdit:9665383] Orlic-Milacic, Marija, 2019-10-30
dbId	9665377
disease	[Disease:1500689] cancer
displayName	ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
hasComponent	[Complex:R-HSA-1225828] CDC37 [cytosol] [CandidateSet:R-HSA-9665347] ERBB2 ECD mutants [plasma membrane] [EntityWithAccessionedSequence:R-HSA-1358718] ERBIN [plasma membrane] [Complex:R-HSA-1221657] HSP90 [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
name	ERBB2 ECD mutants:ERBIN:HSP90:CDC37
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9665377

(input)	[Reaction:R-HSA-9665412] ERBB2 ECD mutants bind TKIs [Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab [Reaction:R-HSA-9665388] ERBB2 ECD mutants heterodimerize with EGFR
(diseaseEntity)	[EntityFunctionalStatus:9665378] gain_of_function of ERBB2 ECD mutants:ERBIN:HSP90:CDC37 [plasma membrane]
(hasComponent)	[Complex:R-HSA-9665468] ERBB2 ECD mutants:ERBIN:HSP90:CDC37:trastuzumab [plasma membrane] [Complex:R-HSA-9665467] ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane]