Reactome | afatinib, neratinib, lapatinib [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9665467] ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9665412] ERBB2 ECD mutants bind TKIs - Homo sapiens [Reaction:R-HSA-9665702] ERBB2 TMD/JMD mutants bind TKIs - Homo sapiens
created	[InstanceEdit:1237432] Orlic-Milacic, Marija, 2011-03-30
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	1237431
disease	[Disease:1500689] cancer
displayName	afatinib, neratinib, lapatinib [cytosol]
hasMember	[ChemicalDrug:R-ALL-1220577] Afatinib [cytosol] [ChemicalDrug:R-ALL-1216527] neratinib [cytosol] [ChemicalDrug:R-ALL-1216521] Lapatinib [cytosol]
inDisease	true
maxDepth	2
modified	[InstanceEdit:9647039] Orlic-Milacic, Marija, 2019-05-30
name	afatinib, neratinib, lapatinib Anti-ERBB2 TKIs Anti-ERBB2 (HER2) tyrosine kinase inhibitors
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-1237431

(input)	[Reaction:R-HSA-9665412] ERBB2 ECD mutants bind TKIs [Reaction:R-HSA-9665702] ERBB2 TMD/JMD mutants bind TKIs
(hasComponent)	[Complex:R-HSA-9665467] ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane]
(activeUnit)	[NegativeRegulation:9665470] Negative regulation by 'ERBB2 ECD mutants:ERBIN:HSP90:CDC37:TKIs [plasma membrane]'

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