Reactome | The internalization of Leishmania amastigotes by macrophages...

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created	[InstanceEdit:9664405] Murillo, Julieth, 2019-10-22
dbId	9664412
displayName	The internalization of Leishmania amastigotes by macrophages...
literatureReference	[LiteratureReference:9664431] Opsonization modulates Rac-1 activation during cell entry by Leishmania amazonensis [LiteratureReference:9664373] Control of infection with Leishmania major in susceptible BALB/c mice lacking the common gamma-chain for FcR is associated with reduced production of IL-10 and TGF-beta by parasitized cells
modified	[InstanceEdit:9670580] Murillo, Julieth, 2019-12-11
schemaClass	Summation
text	The internalization of Leishmania amastigotes by macrophages is thought to be mediated mainly through opsonization with immunoglobulins (Igs) which bind Fc?Rs, stimulating the uptake (Morehead et al 2002 & Padigel et al. 2005). Glycoinositol phospholipids (GIPLs) are the most abundant glycolipids on the surface of the amastigote form of Leishmania parasites and Buxbaum and colleagues showed that IgG1 in mice, binds the GIPL molecules on the amastigote stage of L. mexicana to subsequently induced the phagocytosis through Fc?Rs (Buxbaum 2013).

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