Reactome | p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9656182] activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9656211] MAP2Ks and MAPKs bind to the activated mutant RAF1 complex - Homo sapiens
created	[InstanceEdit:9656175] Rothfels, Karen, 2019-07-27
crossReference	[DatabaseIdentifier:12020787] Mondo:0005045
dbId	9656176
disease	[Disease:9651116] Costello syndrome [Disease:9651118] LEOPARD syndrome [Disease:6802289] Noonan syndrome [Disease:1500689] cancer [Disease:6788675] hypertrophic cardiomyopathy
displayName	p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane]
hasComponent	[Complex:R-HSA-5672715] p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] [DefinedSet:R-HSA-9656165] phosphorylated RAF1 mutants [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
maxDepth	5
name	p21 RAS:GTP:activated RAF1 mutant heterodimers
producedByEvent	[Reaction:R-HSA-9656212] Phosphorylation of RAF1 mutants - Homo sapiens [Reaction:R-HSA-9656209] Dissociation of RAS:RAF1 mutant complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9656176

(hasComponent)	[Complex:R-HSA-9656182] activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] [Complex:R-HSA-9656185] activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] [Complex:R-HSA-9656179] activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane]
(output)	[Reaction:R-HSA-9656209] Dissociation of RAS:RAF1 mutant complex [Reaction:R-HSA-9656212] Phosphorylation of RAF1 mutants
(input)	[Reaction:R-HSA-9656211] MAP2Ks and MAPKs bind to the activated mutant RAF1 complex
(diseaseEntity)	[EntityFunctionalStatus:9656204] gain_of_function of p21 RAS:GTP:activated RAF1 mutant heterodimers [plasma membrane]

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