Reactome | ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)

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ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) Show undefined attributes

authored	[InstanceEdit:9645656] Shamovsky, Veronica, 2019-05-17
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9645472] Shamovsky, Veronica, 2019-05-12
dbId	9645406
displayName	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
edited	[InstanceEdit:9657757] Shamovsky, Veronica, 2019-08-09
eventOf	[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-9645442] Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex - Homo sapiens
input	[Complex:R-HSA-9645508] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol] 2 × [Polymer:R-HSA-450152] K63polyUb [cytosol] 2 × [Complex:R-HSA-450277] TAB1:TAB2,TAB3:TAK1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains [LiteratureReference:208226] TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains [LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
orthologousEvent	[Reaction:R-GGA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Gallus gallus [Reaction:R-XTR-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Xenopus tropicalis [Reaction:R-SSC-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Sus scrofa [Reaction:R-BTA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Bos taurus [Reaction:R-CFA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Canis familiaris [Reaction:R-RNO-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Rattus norvegicus [Reaction:R-MMU-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Mus musculus
output	[Complex:R-HSA-9645445] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol]
precedingEvent	[Polymerisation:R-HSA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Homo sapiens
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9647756] Gillespie, Marc E, 2019-06-03 [InstanceEdit:9652842] Shao, Feng, 2019-07-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9645406
summation	[Summation:9645505] TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...

Referrals

(hasEvent)	[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway
(precedingEvent)	[Reaction:R-HSA-9645442] Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex