Reactome | Alpha-protein kinase 1 signaling pathway

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Alpha-protein kinase 1 signaling pathway Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331821
displayName	Alpha-protein kinase 1 signaling pathway
eventOf	[Pathway:R-CFA-168249] Innate Immune System - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262515] cytoplasmic pattern recognition receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-9645428] ALPK1 binds ADP-heptose - Canis familiaris [Reaction:R-CFA-9645524] ALPK1:ADP-heptose binds TIFA - Canis familiaris [Reaction:R-CFA-9645535] ALPK1 phosphorylates TIFA - Canis familiaris [Reaction:R-CFA-9645481] TIFA oligomerization - Canis familiaris [Reaction:R-CFA-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 - Canis familiaris [Reaction:R-CFA-9645501] TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex - Canis familiaris [BlackBoxEvent:R-CFA-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Canis familiaris [Polymerisation:R-CFA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Canis familiaris [Reaction:R-CFA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Canis familiaris [Reaction:R-CFA-9645442] Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex - Canis familiaris
inferredFrom	[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Alpha-protein kinase 1 signaling pathway ALPK1 signaling pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-9645460
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-168249] Innate Immune System
(inferredTo)	[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway