Reactome | Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer

Schema > BlackBoxEvent > Entries

Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer Show undefined attributes

authored	[InstanceEdit:9645656] Shamovsky, Veronica, 2019-05-17
catalystActivity	[CatalystActivity:9645438] ubiquitin-protein transferase activity of ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol]
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9645472] Shamovsky, Veronica, 2019-05-12
dbId	9645414
displayName	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
edited	[InstanceEdit:9657757] Shamovsky, Veronica, 2019-08-09
eventOf	[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway - Homo sapiens
followingEvent	[Polymerisation:R-HSA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Homo sapiens
input	[Complex:R-HSA-9645440] ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 oligomer [cytosol] 9 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer
orthologousEvent	[BlackBoxEvent:R-GGA-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Gallus gallus [BlackBoxEvent:R-XTR-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Xenopus tropicalis [BlackBoxEvent:R-SSC-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Sus scrofa [BlackBoxEvent:R-BTA-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Bos taurus [BlackBoxEvent:R-CFA-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Canis familiaris [BlackBoxEvent:R-RNO-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Rattus norvegicus [BlackBoxEvent:R-MMU-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Mus musculus
output	[Complex:R-HSA-9645508] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol]
precedingEvent	[Reaction:R-HSA-9645501] TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex - Homo sapiens
releaseDate	2019-09-10
requiredInputComponent	[Complex:R-HSA-202463] UBE2N:UBE2V1 [cytosol] - Homo sapiens
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9647756] Gillespie, Marc E, 2019-06-03 [InstanceEdit:9652842] Shao, Feng, 2019-07-08
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9645414
summation	[Summation:9645446] TNF Receptor Associated Factor 6 (TRAF6) possesses ubiquitin...

Referrals

(hasEvent)	[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway
(precedingEvent)	[Polymerisation:R-HSA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation

Cite Us!