Reactome | ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6

Schema > Reaction > Entries

ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 Show undefined attributes

authored	[InstanceEdit:9645656] Shamovsky, Veronica, 2019-05-17
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9645472] Shamovsky, Veronica, 2019-05-12
dbId	9645520
displayName	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6
edited	[InstanceEdit:9657757] Shamovsky, Veronica, 2019-08-09
eventOf	[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-9645501] TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex - Homo sapiens
input	[Complex:R-HSA-9645404] ALPK1:ADP-heptose:p-T9-TIFA oligomer [cytosol] [EntityWithAccessionedSequence:R-HSA-166366] TRAF6 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9645451] Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose [LiteratureReference:9645463] TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6
orthologousEvent	[Reaction:R-GGA-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 - Gallus gallus [Reaction:R-XTR-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 - Xenopus tropicalis [Reaction:R-SSC-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 - Sus scrofa [Reaction:R-BTA-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 - Bos taurus [Reaction:R-CFA-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 - Canis familiaris [Reaction:R-RNO-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 - Rattus norvegicus [Reaction:R-MMU-9645520] ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6 - Mus musculus
output	[Complex:R-HSA-9645482] ALPK1:ADP-heptose:p-T9-TIFA oligomer:TRAF6 [cytosol]
precedingEvent	[Reaction:R-HSA-9645481] TIFA oligomerization - Homo sapiens
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9647756] Gillespie, Marc E, 2019-06-03 [InstanceEdit:9652842] Shao, Feng, 2019-07-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9645520
summation	[Summation:9645478] A fluorescence-activated cell sorting (FACS)-based, genome-w...

Referrals

(hasEvent)	[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway
(precedingEvent)	[Reaction:R-HSA-9645501] TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex