Reactome | PRKCZ autophosphorylates downstream of estrogen stimulation

Schema > Reaction > Entries

PRKCZ autophosphorylates downstream of estrogen stimulation Show undefined attributes

authored	[InstanceEdit:9632125] Rothfels, Karen, 2018-12-14
catalystActivity	[CatalystActivity:9632839] protein serine/threonine kinase activity of PDPK1:PIP3:p-T410-PRKCZ [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9632859] Rothfels, Karen, 2018-12-21
dbId	9632858
displayName	PRKCZ autophosphorylates downstream of estrogen stimulation
eventOf	[Pathway:R-HSA-9634635] Estrogen-stimulated signaling through PRKCZ - Homo sapiens
followingEvent	[Reaction:R-HSA-9632906] PRKCZ recruits RAS in response to estrogen stimulation - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-437184] PDPK1:PIP3:p-T410-PRKCZ [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9632798] Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PRKCZ autophosphorylates downstream of estrogen stimulation
orthologousEvent	[Reaction:R-SCE-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Saccharomyces cerevisiae [Reaction:R-SPO-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Schizosaccharomyces pombe [Reaction:R-DDI-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Dictyostelium discoideum [Reaction:R-CEL-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Caenorhabditis elegans [Reaction:R-DME-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Drosophila melanogaster [Reaction:R-GGA-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Gallus gallus [Reaction:R-SSC-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Sus scrofa [Reaction:R-BTA-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Bos taurus [Reaction:R-CFA-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Canis familiaris [Reaction:R-RNO-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Rattus norvegicus [Reaction:R-MMU-9632858] PRKCZ autophosphorylates downstream of estrogen stimulation - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9632853] PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane]
precedingEvent	[Reaction:R-HSA-437195] PDPK1 activates PRKCZ - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9637806] Levin, Ellis R, 2019-02-19 [InstanceEdit:9645003] Acconcia, Filippo, 2019-04-24 [InstanceEdit:9645002] Marino, Maria, 2019-04-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9632858
summation	[Summation:9632856] PKC zeta (PRKCZ) is serine phosphorylated downstream of ESR1...

Referrals

(hasEvent)	[Pathway:R-HSA-9634635] Estrogen-stimulated signaling through PRKCZ
(precedingEvent)	[Reaction:R-HSA-9632906] PRKCZ recruits RAS in response to estrogen stimulation