PKC zeta (PRKCZ) is serine phosphorylated downstream of ESR1...

created [InstanceEdit:9632857] Rothfels, Karen, 2018-12-21
dbId 9632856
displayName PKC zeta (PRKCZ) is serine phosphorylated downstream of ESR1...
schemaClass Summation
text PKC zeta (PRKCZ) is serine phosphorylated downstream of ESR1 and estradiol stimulation. Serine phosphorylation is required for recruitment of RAS to the ESR1 complex, the estrogen-stimulated translocation of ERK2 to the nucleus and for entry into S phase (Castoria et al, 2004). Mutation of threonine 410, which is required for PRKCZ activation, abolishes serine phosphorylation, suggesting the enzyme autophosphorylates (Castoria et al, 2004).
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