Reactome | PRKCZ autophosphorylates downstream of estrogen stimulation

PRKCZ autophosphorylates downstream of estrogen stimulation

Stable Identifier

R-HSA-9632858

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PRKCZ autophosphorylates downstream of estrogen stimulation

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PKC zeta (PRKCZ) is serine phosphorylated downstream of ESR1 and estradiol stimulation. Serine phosphorylation is required for recruitment of RAS to the ESR1 complex, the estrogen-stimulated translocation of ERK2 to the nucleus and for entry into S phase (Castoria et al, 2004). Mutation of threonine 410, which is required for PRKCZ activation, abolishes serine phosphorylation, suggesting the enzyme autophosphorylates (Castoria et al, 2004).

Literature References

PubMed ID	Title	Journal	Year
15314172	Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells Castoria, G, Migliaccio, A, Di Domenico, M, Lombardi, M, de Falco, A, Varricchio, L, Bilancio, A, Barone, MV, Auricchio, F	Mol. Cell. Biol.	2004