PRKCZ autophosphorylates downstream of estrogen stimulation

Stable Identifier
R-HSA-9632858
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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PRKCZ autophosphorylates downstream of estrogen stimulation
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PKC zeta (PRKCZ) is serine phosphorylated downstream of ESR1 and estradiol stimulation. Serine phosphorylation is required for recruitment of RAS to the ESR1 complex, the estrogen-stimulated translocation of ERK2 to the nucleus and for entry into S phase (Castoria et al, 2004). Mutation of threonine 410, which is required for PRKCZ activation, abolishes serine phosphorylation, suggesting the enzyme autophosphorylates (Castoria et al, 2004).

Literature References
PubMed ID Title Journal Year
15314172 Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells

Castoria, G, Migliaccio, A, Di Domenico, M, Lombardi, M, de Falco, A, Varricchio, L, Bilancio, A, Barone, MV, Auricchio, F

Mol. Cell. Biol. 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein kinase C activity of PDPK1:PIP3:p-T410-PRKCZ [plasma membrane]
Physical Entity
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane]
Activity
protein kinase C activity (0004697)
Orthologous Events
PRKCZ autophosphorylates downstream of estrogen stimulation (Bos taurus)
PRKCZ autophosphorylates downstream of estrogen stimulation (Caenorhabditis elegans)
PRKCZ autophosphorylates downstream of estrogen stimulation (Canis familiaris)
PRKCZ autophosphorylates downstream of estrogen stimulation (Danio rerio)
PRKCZ autophosphorylates downstream of estrogen stimulation (Dictyostelium discoideum)
PRKCZ autophosphorylates downstream of estrogen stimulation (Drosophila melanogaster)
PRKCZ autophosphorylates downstream of estrogen stimulation (Gallus gallus)
PRKCZ autophosphorylates downstream of estrogen stimulation (Mus musculus)
PRKCZ autophosphorylates downstream of estrogen stimulation (Rattus norvegicus)
PRKCZ autophosphorylates downstream of estrogen stimulation (Saccharomyces cerevisiae)
PRKCZ autophosphorylates downstream of estrogen stimulation (Schizosaccharomyces pombe)
PRKCZ autophosphorylates downstream of estrogen stimulation (Sus scrofa)
PRKCZ autophosphorylates downstream of estrogen stimulation (Xenopus tropicalis)
Authored
Rothfels, K  (2018-12-14)
Reviewed
Levin, ER  (2019-02-19)
Acconcia, F  (2019-04-24)
Marino, M  (2019-04-24)
Created
Rothfels, K  (2018-12-21)