PRKCZ autophosphorylates downstream of estrogen stimulation

Stable Identifier
R-HSA-9632858
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PKC zeta (PRKCZ) is serine phosphorylated downstream of ESR1 and estradiol stimulation. Serine phosphorylation is required for recruitment of RAS to the ESR1 complex, the estrogen-stimulated translocation of ERK2 to the nucleus and for entry into S phase (Castoria et al, 2004). Mutation of threonine 410, which is required for PRKCZ activation, abolishes serine phosphorylation, suggesting the enzyme autophosphorylates (Castoria et al, 2004).

Literature References
PubMed ID Title Journal Year
15314172 Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells

Castoria, G, Migliaccio, A, Di Domenico, M, Lombardi, M, de Falco, A, Varricchio, L, Bilancio, A, Barone, MV, Auricchio, F

Mol. Cell. Biol. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein kinase C activity of PDPK1:PIP3:p-T410-PRKCZ [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created