Reactome | ESR1-dependent CCND1 expression

ESR1-dependent CCND1 expression

Stable Identifier

R-HSA-9623355

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

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Expression of CCND1, the gene encoding cyclin D1, is stimulated by treatment of cells with E2. Expression is dependent on ESR1-mediated signaling through the PKA and AKT pathways, and consistent with this, levels of phosphorylated CREB1 increase upon treatment with E2. The CCND1 promoter has a CRE element that is bound by phosphorylated CREB1 upon E2 treatment as assessed by electrophoretic mobility shift assay (Park et al, 2001; Felty et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
15897899	Estrogen-induced G1/S transition of G0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling Felty, Q, Singh, KP, Roy, D	Oncogene	2005
11243864	Reduction in cyclin D1/Cdk4/retinoblastoma protein signaling by CRE-decoy oligonucleotide Park, YG, Park, S, Lim, SO, Lee, MS, Ryu, CK, Kim, I, Cho-Chung, YS	Biochem. Biophys. Res. Commun.	2001