Reactome | KAT2B,EP300 acetylate FOXO3 under oxidative stress

Schema > Reaction > Entries

KAT2B,EP300 acetylate FOXO3 under oxidative stress Show undefined attributes

catalystActivity	[CatalystActivity:10432303] protein-lysine-acetyltransferase activity of KAT2B,(EP300) [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10432305
displayName	KAT2B,EP300 acetylate FOXO3 under oxidative stress
eventOf	[Pathway:R-BTA-9617629] Regulation of FOXO transcriptional activity by acetylation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-9620532] SIRT1,SIRT3 deacetylate FOXO3 - Bos taurus
inferredFrom	[Reaction:R-HSA-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress - Homo sapiens
input	5 × [SimpleEntity:R-ALL-113560] Ac-CoA [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-199305] FOXO3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	KAT2B,EP300 acetylate FOXO3 under oxidative stress
output	5 × [SimpleEntity:R-ALL-2485002] CoA-SH [nucleoplasm] [EntityWithAccessionedSequence:R-BTA-9620514] FOXO3 [nucleoplasm]
regulatedBy	[PositiveRegulation:9620522] Positive regulation by 'ROS [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-9620515
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-9617629] Regulation of FOXO transcriptional activity by acetylation
(precedingEvent)	[Reaction:R-BTA-9620532] SIRT1,SIRT3 deacetylate FOXO3
(inferredTo)	[Reaction:R-HSA-9620515] KAT2B,EP300 acetylate FOXO3 under oxidative stress

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