Reactome | Egr2, Sox10 and Smarca4 bind the Mpz gene

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Egr2, Sox10 and Smarca4 bind the Mpz gene Show undefined attributes

authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9614792] Rothfels, Karen, 2018-07-27
dbId	9614784
displayName	Egr2, Sox10 and Smarca4 bind the Mpz gene
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[EntityWithAccessionedSequence:R-RNO-9614791] Egr2 [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-9614786] Mpz gene [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-9614783] Smarca4 [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-9614292] Sox10 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9613746] Direct regulation of myelin protein zero expression by the Egr2 transactivator [LiteratureReference:9613730] Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10 [LiteratureReference:9613726] SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression [LiteratureReference:9614767] Protein zero gene expression is regulated by the glial transcription factor Sox10
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Egr2, Sox10 and Smarca4 bind the Mpz gene
orthologousEvent	[Reaction:R-HSA-9614790] EGR2, SOX10 and SMARCA4 bind the MPZ gene - Homo sapiens
output	[Complex:R-RNO-9614781] Mpz gene:Egr2:Sox10:Smarca4 [nucleoplasm]
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9614784
summation	[Summation:9614788] Myelin protein zero (Mpz) is a primary component of the myel...

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