EGR2, SOX10 and SMARCA4 bind the MPZ gene

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R-HSA-9614790
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Reaction
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Homo sapiens
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MPZ is a key component of the myelin sheath that surrounds axons of the peripheral nervous system. Expression of MPZ is dependent on binding of transcriptional regulators EGR2 and SOX10 to response elements in intron 1, where they recruit SMARCA4 to the gene (Le Blanc et al, 2006; Le Blanc et al, 2007; Marathe et al, 2013). SOX10 additionally binds to elements in the promoter of MPZ (Peirano et al, 2000).

Literature References
PubMed ID Title Journal Year
10757804 Protein zero gene expression is regulated by the glial transcription factor Sox10

Goerich, DE, Wegner, M, Riethmacher, D, Peirano, RI

Mol. Cell. Biol. 2000
23874858 SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression

Yeung, KC, Datar, I, Zhang, X, Mehta, G, Marathe, HG, Mehrotra, A, de la Serna, IL

PLoS ONE 2013
17325040 Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10

Ward, RM, Svaren, J, Leblanc, SE

Mol. Cell. Biol. 2007
16373334 Direct regulation of myelin protein zero expression by the Egr2 transactivator

Wrabetz, L, Ward, RM, Svaren, J, Jang, SW, Leblanc, SE

J. Biol. Chem. 2006
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