p-S133 CREB and p-S103 SRF bind the EGR1 promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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Expression of EGR1 depends in part on the binding of phosphorylated CREB and SRF factors to their cognate sites in the promoter (Quereshi et al, 1991; Alexandre et al, 1991; McMahon et al, 1995; Chen et al, 2004; Vickers et al, 2004; Tyan et al, 2008; David et al, 2005; Esnault et al, 2017). Phosphorylation of CREB can be mediated by RSK proteins, MAPKAPK2 or by SGK (de Cesare et al, 1998; Bonni et al, 1995; David et al, 2005; Tyan et al, 2008). SGK-mediated phosphorylation of SRF has also been implicated in the activation of EGR1 gene expression (Tyan et al, 2008).

Literature References
PubMed ID Title Journal Year
28286024 ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription

Kelly, G, Treisman, R, Stewart, A, Gualdrini, F, East, P, Esnault, C, Matthews, N, Horswell, S

Mol. Cell 2017
1833716 Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements

Alexandre, C, Verrier, B, Charnay, P

Oncogene 1991
15542842 Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death

Kasza, A, Seifert, A, Kurnaz, IA, Zeef, LA, Hayes, A, O'Donnell, A, Sharrocks, AD, Vickers, ER

Mol. Cell. Biol. 2004
9770464 Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene

Jacquot, S, Hanauer, A, De Cesare, D, Sassone-Corsi, P

Proc Natl Acad Sci U S A 1998
15449318 Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1

Lee, WR, Safe, S, Chen, CC

J. Cell. Biochem. 2004
15733869 Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB

David, S, Kalb, RG

FEBS Lett. 2005
2040600 v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements

Cao, XM, Foster, DA, Sukhatme, VP, Qureshi, SA

J. Biol. Chem. 1991
18088355 Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation

Lin, CL, Lee, EH, Ma, YL, Tyan, SW, Tsai, MC

J. Neurochem. 2008
7551568 Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals

Bonni, A, Dudek, H, Greenberg, ME, Ginty, DD

Mol. Cell. Neurosci. 1995
7823924 A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes

McMahon, SB, Monroe, JG

Mol. Cell. Biol. 1995
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