Expression of EGR1 depends in part on the binding of phosphorylated CREB and SRF factors to their cognate sites in the promoter (Quereshi et al, 1991; Alexandre et al, 1991; McMahon et al, 1995; Chen et al, 2004; Vickers et al, 2004; Tyan et al, 2008; David et al, 2005; Esnault et al, 2017). Phosphorylation of CREB can be mediated by RSK proteins, MAPKAPK2 or by SGK (de Cesare et al, 1998; Bonni et al, 1995; David et al, 2005; Tyan et al, 2008). SGK-mediated phosphorylation of SRF has also been implicated in the activation of EGR1 gene expression (Tyan et al, 2008).
Kelly, G, Treisman, R, Stewart, A, Gualdrini, F, East, P, Esnault, C, Matthews, N, Horswell, S
Alexandre, C, Verrier, B, Charnay, P
Kasza, A, Seifert, A, Kurnaz, IA, Zeef, LA, Hayes, A, O'Donnell, A, Sharrocks, AD, Vickers, ER
Jacquot, S, Hanauer, A, De Cesare, D, Sassone-Corsi, P
Lee, WR, Safe, S, Chen, CC
David, S, Kalb, RG
Cao, XM, Foster, DA, Sukhatme, VP, Qureshi, SA
Lin, CL, Lee, EH, Ma, YL, Tyan, SW, Tsai, MC
Bonni, A, Dudek, H, Greenberg, ME, Ginty, DD
McMahon, SB, Monroe, JG
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