Reactome | RSK1/2/3 phosphorylates CREB at Serine 119

Schema > Reaction > Entries

RSK1/2/3 phosphorylates CREB at Serine 119 Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:199892] protein serine/threonine kinase activity of Phospho-Ribosomal protein S6 kinase [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:199916] Jassal, B, 2007-07-13 13:44:04
dbId	199895
displayName	RSK1/2/3 phosphorylates CREB at Serine 119
eventOf	[Pathway:R-HSA-199920] CREB phosphorylation - Homo sapiens [Pathway:R-HSA-881907] Gastrin-CREB signalling pathway via PKC and MAPK - Homo sapiens
followingEvent	[Reaction:R-HSA-9612514] p-S133 CREB and p-S103 SRF bind the EGR1 promoter - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-52777] CREB1 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199893] Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	RSK1/2/3 phosphorylates CREB at Serine 119
orthologousEvent	[Reaction:R-CEL-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Caenorhabditis elegans [Reaction:R-DME-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Drosophila melanogaster [Reaction:R-GGA-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Gallus gallus [Reaction:R-XTR-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Xenopus tropicalis [Reaction:R-SSC-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Sus scrofa [Reaction:R-BTA-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Bos taurus [Reaction:R-CFA-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Canis familiaris [Reaction:R-RNO-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Rattus norvegicus [Reaction:R-MMU-199895] RSK1/2/3 phosphorylates CREB at Serine 119 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-111910] p-S133-CREB1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-198746] ERK1/2/5 activate RSK1/2/3 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-199895
summation	[Summation:199924] CREB is phosphorylated at S133 by RSK1/2/3.

Referrals

(hasEvent)	[Pathway:R-HSA-881907] Gastrin-CREB signalling pathway via PKC and MAPK [Pathway:R-HSA-199920] CREB phosphorylation
(precedingEvent)	[Reaction:R-HSA-9612514] p-S133 CREB and p-S103 SRF bind the EGR1 promoter