Reactome | Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF

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Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF Show undefined attributes

catalystActivity	[CatalystActivity:10545199] protein serine/threonine kinase activity of RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane]
category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10545201
displayName	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
eventOf	[Pathway:R-SSC-170968] Frs2-mediated activation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Sus scrofa
inferredFrom	[Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-9610134] RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-9610136] RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane]
precedingEvent	[Reaction:R-SSC-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Sus scrofa [Reaction:R-SSC-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9610153
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-170968] Frs2-mediated activation
(precedingEvent)	[Reaction:R-SSC-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
(inferredTo)	[Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF

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