Reactome | Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF

Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF

Stable Identifier

R-HSA-9610153

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endosome membrane, cytosol

ReviewStatus

5/5

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Prolonged ERK activation events (Homo sapiens)
        
        Frs2-mediated activation (Homo sapiens)
        
        Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Homo sapiens)

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Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF

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Downstream of NGF stimulation, activated BRAF phosphorylates MAP2K1 and MAP2K2 (MEK1 and MEK2) at the endosome, leading to sustained MAPK signaling (York et al, 1998; Kao et al, 2001; reviewed in Huang and Reichardt, 2003; Reichardt, 2006).

Literature References

PubMed ID	Title	Journal	Year
11278445	Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells Kao, S, Jaiswal, RK, Kolch, W, Landreth, GE	J Biol Chem	2001
16939974	Neurotrophin-regulated signalling pathways Reichardt, LF	Philos Trans R Soc Lond B Biol Sci	2006
9560161	Rap1 mediates sustained MAP kinase activation induced by nerve growth factor York, RD, Yao, H, Dillon, T, Ellig, CL, Eckert, SP, McCleskey, EW, Stork, PJ	Nature	1998
12676795	Trk receptors: roles in neuronal signal transduction Huang, EJ, Reichardt, LF	Annu Rev Biochem	2003