Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF

Stable Identifier
Reaction [transition]
Homo sapiens
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Downstream of NGF stimulation, activated BRAF phosphorylates MAP2K1 and MAP2K2 (MEK1 and MEK2) at the endosome, leading to sustained MAPK signaling (York et al, 1998; Kao et al, 2001; reviewed in Huang and Reichardt, 2003; Reichardt, 2006).

Literature References
PubMed ID Title Journal Year
16939974 Neurotrophin-regulated signalling pathways

Reichardt, LF

Philos Trans R Soc Lond B Biol Sci 2006
11278445 Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

Kao, S, Jaiswal, RK, Kolch, W, Landreth, GE

J Biol Chem 2001
9560161 Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

York, RD, Yao, H, Dillon, T, Ellig, CL, Eckert, SP, McCleskey, EW, Stork, PJ

Nature 1998
12676795 Trk receptors: roles in neuronal signal transduction

Huang, EJ, Reichardt, LF

Annu Rev Biochem 2003
Participant Of
Catalyst Activity
Catalyst Activity
protein serine/threonine kinase activity of RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane]
Physical Entity
Orthologous Events
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