Reactome | Activated BRAF recruits MAP2Ks and MAPKs to the endosome

Schema > Reaction > Entries

Activated BRAF recruits MAP2Ks and MAPKs to the endosome Show undefined attributes

category	binding
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10638819
displayName	Activated BRAF recruits MAP2Ks and MAPKs to the endosome
eventOf	[Pathway:R-DRE-170968] Frs2-mediated activation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Danio rerio
inferredFrom	[Reaction:R-HSA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Homo sapiens
input	[DefinedSet:R-DRE-5672716] MAP2K homo/heterodimers [cytosol] [DefinedSet:R-DRE-169291] MAPKs [cytosol] [Complex:R-DRE-9610130] RAP1:GTP:activated BRAF dimer [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated BRAF recruits MAP2Ks and MAPKs to the endosome
output	[Complex:R-DRE-9610134] RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane]
precedingEvent	[Reaction:R-DRE-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-9610152
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-170968] Frs2-mediated activation
(precedingEvent)	[Reaction:R-DRE-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
(inferredTo)	[Reaction:R-HSA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome

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