Reactome | Activated BRAF recruits MAP2Ks and MAPKs to the endosome

Activated BRAF recruits MAP2Ks and MAPKs to the endosome

Stable Identifier

R-HSA-9610152

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endosome membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Prolonged ERK activation events (Homo sapiens)
        
        Frs2-mediated activation (Homo sapiens)
        
        Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Homo sapiens)

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Activated BRAF recruits MAP2Ks and MAPKs to the endosome

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Downstream of NGF stimulation and RAP1 activation, BRAF recruits MAP2Ks and MAPKs to the endosome to promote sustained RAF/MAPK signaling (York et al, 1998; reviewed in Reichardt, 2006; Barford et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
27503831	The neurotrophin receptor signaling endosome: Where trafficking meets signaling Barford, K, Deppmann, C, Winckler, B	Dev Neurobiol	2017
16939974	Neurotrophin-regulated signalling pathways Reichardt, LF	Philos Trans R Soc Lond B Biol Sci	2006
9560161	Rap1 mediates sustained MAP kinase activation induced by nerve growth factor York, RD, Yao, H, Dillon, T, Ellig, CL, Eckert, SP, McCleskey, EW, Stork, PJ	Nature	1998