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Schema
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Reaction
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Entries
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
Show undefined attributes
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authored
[InstanceEdit:9606150] May, Bruce, 2018-04-14
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9606166] May, Bruce, 2018-04-19
dbId
9606151
displayName
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
edited
[InstanceEdit:9606150] May, Bruce, 2018-04-14
eventOf
[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9606163] p-SYK and LYN phosphorylate BTK - Homo sapiens
input
[Complex:R-HSA-983687] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-197948] BTK [cytosol]
[EntityWithAccessionedSequence:R-HSA-197954] NCK1 [cytosol]
2 ×
[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-984806] PLCG2 [cytosol]
[EntityWithAccessionedSequence:R-HSA-195066] VAV1 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1169540] BLNK mediates Syk-dependent Btk activation
[LiteratureReference:983502] BLNK: a central linker protein in B cell activation
[LiteratureReference:983470] BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins
[LiteratureReference:2076210] SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation
[LiteratureReference:9606867] Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling
[LiteratureReference:2076207] The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85
[LiteratureReference:9613685] Interaction of SLP adaptors with the SH2 domain of Tec family kinases
modified
[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
orthologousEvent
[Reaction:R-SSC-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Sus scrofa
[Reaction:R-BTA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Bos taurus
[Reaction:R-CFA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Canis familiaris
[Reaction:R-RNO-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Rattus norvegicus
[Reaction:R-MMU-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Mus musculus
output
[Complex:R-HSA-9606167] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-983703] p-6Y-SYK phosphorylates BLNK (SLP65) - Homo sapiens
releaseDate
2018-09-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9613695] Wienands, J, 2018-07-18
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9606151
summation
[Summation:9606897] Phosphorylated BLNK (also called BASH or SLP-65) at the plas...
Referrals
(hasEvent)
[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(precedingEvent)
[BlackBoxEvent:R-HSA-9606163] p-SYK and LYN phosphorylate BTK
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