Reactome | Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1

Schema > Reaction > Entries

Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 Show undefined attributes

authored	[InstanceEdit:9606150] May, Bruce, 2018-04-14
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9606166] May, Bruce, 2018-04-19
dbId	9606151
displayName	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
edited	[InstanceEdit:9606150] May, Bruce, 2018-04-14
eventOf	[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9606163] p-SYK and LYN phosphorylate BTK - Homo sapiens
input	[Complex:R-HSA-983687] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-197948] BTK [cytosol] [EntityWithAccessionedSequence:R-HSA-197954] NCK1 [cytosol] 2 × [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-984806] PLCG2 [cytosol] [EntityWithAccessionedSequence:R-HSA-195066] VAV1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1169540] BLNK mediates Syk-dependent Btk activation [LiteratureReference:983502] BLNK: a central linker protein in B cell activation [LiteratureReference:983470] BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins [LiteratureReference:2076210] SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation [LiteratureReference:9606867] Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling [LiteratureReference:2076207] The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85 [LiteratureReference:9613685] Interaction of SLP adaptors with the SH2 domain of Tec family kinases
modified	[InstanceEdit:10314670] Wright, Adam, 2024-03-07
name	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
orthologousEvent	[Reaction:R-SSC-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Sus scrofa [Reaction:R-BTA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Bos taurus [Reaction:R-CFA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Canis familiaris [Reaction:R-RNO-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Rattus norvegicus [Reaction:R-MMU-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Mus musculus
output	[Complex:R-HSA-9606167] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-983703] p-6Y-SYK phosphorylates BLNK (SLP65) - Homo sapiens
releaseDate	2018-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9613695] Wienands, J, 2018-07-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9606151
summation	[Summation:9606897] Phosphorylated BLNK (also called BASH or SLP-65) at the plas...

Referrals

(hasEvent)	[Pathway:R-HSA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(precedingEvent)	[BlackBoxEvent:R-HSA-9606163] p-SYK and LYN phosphorylate BTK