Reactome | PLCG2 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PLCG2 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-5621157] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] - Homo sapiens [Complex:R-HSA-9606886] p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5621356] PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G - Homo sapiens [Reaction:R-HSA-9606894] p-DAPP1 (p-BAM32) binds PLCG2 - Homo sapiens [Reaction:R-HSA-5607745] 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG - Homo sapiens [BlackBoxEvent:R-HSA-9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated - Homo sapiens [Reaction:R-HSA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 - Homo sapiens
created	[InstanceEdit:984801] May, B, 2010-11-03
dbId	984806
deleted	[Deleted:9763706] Deletion of instance: 1604645
displayName	PLCG2 [cytosol]
endCoordinate	1265
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-5607628] Plcg2 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-984806] Plcg2 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-984806] PLCG2 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-984806] PLCG2 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-984806] PLCG2 [cytosol] - Sus scrofa [GenomeEncodedEntity:R-DRE-984806] Ghost homologue of PLCG2 [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-XTR-984806] plcg2 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-984806] PLCG2 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-984806] sl [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-984806] plc-3 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-984806] PLCG2 [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-984806] PLCG2 [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-984806] PLCG2 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-PFA-984806] PLCG2 [cytosol] - Plasmodium falciparum
literatureReference	[LiteratureReference:984795] Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor
maxDepth	1
memberOf	[DefinedSet:R-HSA-1169089] PLC gamma1,2 [cytosol] - Homo sapiens
modified	[InstanceEdit:3632907] Wu, G, 2013-05-28
name	PLCG2 Phospholipase C gamma 2 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 PLCG2_HUMAN
positivelyRegulates	[PositiveRegulation:R-HSA-2201314] Positive regulation by 'PLCG2 [cytosol]'
referenceEntity	[ReferenceGeneProduct:uniprot:P16885] UniProt:P16885 PLCG2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-984806
startCoordinate	1

Referrals

(replacementInstances)	[Deleted:9763706] Deletion of instance: 1604645
(input)	[BlackBoxEvent:R-HSA-9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated [Reaction:R-HSA-5621356] PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G [Reaction:R-HSA-9606894] p-DAPP1 (p-BAM32) binds PLCG2 [Reaction:R-HSA-5607745] 1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG [Reaction:R-HSA-9606151] Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
(hasComponent)	[Complex:R-HSA-5621157] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] [Complex:R-HSA-9606886] p-Y139-DAPP1:PLCG2:PIP3 [plasma membrane] [Complex:R-HSA-9606170] PLCG2:PIP3 [plasma membrane]
(regulator)	[PositiveRegulation:R-HSA-2201314] Positive regulation by 'PLCG2 [cytosol]'
(hasMember)	[DefinedSet:R-HSA-1169089] PLC gamma1,2 [cytosol]

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